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在表面食道状细胞癌中,淋巴结转移的危险因素和预测性诺基图
Jin Wang1, Xian Zhang2, Tao Gan1
1Department of Gastroenterology and Hepatology, Sichuan University-University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
World journal of gastroenterology
|January 8, 2024
概括
这项研究开发了一种名图,用于预测表面食道状细胞癌 (ESCC) 中的淋巴结转移风险 (LNM). 该工具有助于为接受内镜切除的患者做出治疗决策.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 手术瘤学手术瘤学
背景情况:
- 表面食道状细胞癌 (ESCC) 涉及粘膜和亚粘膜的透.
- 内镜切除适用于低风险的ESCC;高风险的病例需要进一步治疗.
- 准确评估淋巴结转移风险对于指导治疗决策至关重要.
研究的目的:
- 在表面的ESCC中识别与LNM相关的风险因素.
- 开发和验证LNM风险在表面ESCC患者的预测性名录.
主要方法:
- 对474名接受食道切除 (2009-2016) 的表面ESCC患者进行了回顾性分析.
- 后勤回归分析以确定LNM风险因素.
- 使用ROC曲线分析构建和验证名图.使用ROC曲线分析.
主要成果:
- 在内瘤中,LNM的患病率为3.29%,在内瘤中为26.40%,在下内瘤中为26.40%.
- 显著的LNM预测因素包括瘤大小,入侵深度,分化,生长模式,芽和淋巴血管入侵.
- 诺米图表显示出良好的预测准确性 (AUC 0.789培训,0.827验证).
结论:
- 一个经过验证的名图有效地预测了表面ESCC中的LNM风险.
- 这种工具可以帮助患者在内镜切除后的临床决策.
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