亚马逊地区的儿童中枢神经系统感染:临床和实验室资料
Eveny Perlize Melo Marinho1, Ewerton da Silva Ferreira1, Caio Cesar Leiva Bastos Barrionuevo1
1Universidade Federal do Amazonas, Manaus, Brazil.
Frontiers in public health
|January 8, 2024
概括
儿童中枢神经系统 (CNS) 感染是严重的. 这项研究在儿科中枢神经系统感染中确定了常见的细菌和病毒病原体,强调了预防策略的必要性.
科学领域:
- 儿童传染病 儿童传染病
- 神经科学是一个神经科学.
- 微生物学 微生物学
背景情况:
- 中枢神经系统 (CNS) 感染带来重大风险,包括儿童的死亡率,发病率,听力损失和神经系统的后果.
- 了解儿科中枢神经系统感染的临床和实验室概况对于有效管理至关重要.
研究的目的:
- 描述诊断为中枢神经系统感染的儿科患者的临床和实验室特征.
- 识别导致儿童中枢神经系统感染的常见病因病因.
主要方法:
- 在2014年1月至2019年12月期间,使用儿科患者 (3个月至15岁) 怀疑中枢神经系统感染的病历进行了横截面研究.
- 脑脊液 (CSF) 样本使用格拉姆染色,培养,分子诊断 (PCR,qPCR) 和血清学进行分析,以确认病原体.
主要成果:
- 在689名患者中,108名 (15.6%) 患有实验室确认的中枢神经系统感染.
- 关键的细菌病原体包括*Neisseria meningitidis*血清组C,*Streptococcus pneumoniae*和*Haemophilus influenzae*.这些细菌病原体可能会导致脑膜炎.
- 确定的病毒包括肠道病毒,细胞巨乳病毒,疹病毒,爱斯坦-巴尔病毒和树状病毒. 与细菌感染相比,病毒感染与意识改变有关.
结论:
- 该研究确定了可预防疫苗的显著细菌病原体和多种病毒家族,导致儿童患者中枢神经系统感染.
- 这些发现强调了持续监测和针对儿童中枢神经系统感染的疫苗接种计划的重要性.
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