献血者中的NAT产量:一项观察性研究
Ankit Sharma1, Sunita Bundas1, Rashmi Parashar2
1Department of Immunohematology and Transfusion Medicine, SMS Medical College and Hospital, Jaipur, Rajasthan, India.
Journal of family medicine and primary care
|January 8, 2024
概括
个人捐献核酸测试 (ID-NAT) 在0.09%的献血者中检测到输血传染性病毒感染 (TTIs). 这种敏感的方法可以识别传统查遗漏的感染,提高了血液的安全性.
科学领域:
- 输血医学 输血医学
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 个人捐赠核酸检测 (ID-NAT) 是一种高度敏感的检测病毒输血传染性感染 (TTIs) 的方法.
- 像ELISA这样的传统查方法可能会错过非血清转化或延迟血清转化捐赠者的感染.
- 通过先进的查技术提高血液安全对于公共卫生至关重要.
研究的目的:
- 在印度北部的一家三级医疗中心分析ID-NAT的结果.
- 评估 ID-NAT 在不同捐赠人群的产量,包括年龄,性别和血型.
- 评估ID-NAT在识别传统查遗漏的病毒感染方面的有效性.
主要方法:
- 对ID-NAT结果进行了回顾性分析.
- 在2019年6月至2021年12月期间,从18,313名显然健康的成年献血者收集了数据.
- 用ID-NAT测试了捐赠者,并根据年份,病毒标记物和捐赠者特征分析了结果.
主要成果:
- 整体NAT收益率为1017分之一 (0.09%).
- 具体的NAT产量是:HBV1在1077年,HCV1在1833年,没有HIV产量.
- 每年NAT收益率有所变化,754年 (2019年) 的1%,2368年 (2020年) 的1%,741年 (2021年) 的1%.
结论:
- 通过检测ELISA错过的感染,特别是隐藏的乙型肝炎,ID-NAT显著提高了血液安全性.
- 该研究强调了ID-NAT在识别非血清转化或延迟血清转化感染方面的重要性.
- 实施ID-NAT对于预防输血传播病毒感染的综合战略至关重要.
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