单细胞分析确定了phospholysine phosphohistidine无机酸盐酸酶作为性结肠炎的标
Yan-Fei Wang1, Ruo-Yu He1, Chan Xu2
1Department of Gastroenterology, The Third Affiliated Hospital of Zhejiang Chinese Medical University, No. 219 Moganshan Road, Xihu District, Hangzhou 310005, Zhejiang Province, China.
World journal of gastroenterology
|January 8, 2024
概括
性结肠炎 (UC) 涉及持续的炎症. 这项研究确定了phospholysine phosphohistidine无机酸盐酸酶 (LHPP) 下调作为一个关键因素,这表明LHPP是UC的潜在治疗标.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 性结肠炎 (UC) 是一种慢性炎症性肠病,具有增加结肠直肠癌风险.
- 单细胞RNA测序 (scRNA-seq) 提供了关于UC复杂细胞机制的见解.
研究的目的:
- 用scRNA-seq.分析UC中的细胞相互作用和分子特征.
- 为了确定性结肠炎的潜在治疗点.
主要方法:
- 整合和分析来自UC患者的scRNA-seq数据.
- 在临床样本上进行mRNA和蛋白质水平测定.
- 病理学相关的染色试验.
主要成果:
- 炎症通路的升级和UC中受损的内皮细胞的特征.
- 与信号传感器和转录激活器相关的聚酸酸酸酶 (LHPP) 的降低调节 3.
- 在UC组织和血中,LHPP显著下调.
结论:
- LHPP下调是UC病理学的一个关键特征.
- 性结肠炎的LHPP是一个潜在的治疗标.
- LHPP在调节与UC相关的炎症方面发挥着作用.
更多相关视频
10:52Radiolabeling and Quantification of Cellular Levels of Phosphoinositides by High Performance Liquid Chromatography-coupled Flow Scintillation
Published on: January 6, 2016
10.4K
09:22Absolute Quantitation of Inositol Pyrophosphates by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry
Published on: August 13, 2021
2.3K
相关概念视频
Phosphoinositides and PIPs
8.5K
Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
8.5K
Protein Kinases and Phosphatases
13.2K
Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
13.2K
