尿液MMP7作为损伤生物标志物
Alejandro Avello1, Juan Guerrero-Mauvecin1, Ana Belen Sanz1,2
1Laboratory of Experimental Nephrology, IIS-Fundacion Jimenez Diaz UAM, Madrid, Spain.
Clinical kidney journal
|January 8, 2024
概括
矩阵金属蛋白酶7 (MMP-7) 在损伤中被上调,并显示出作为生物标记物的潜力. 研究强调其与纤维化和功能下降的关联,提供有希望的诊断见解.
科学领域:
- 生物化学和分子生物学
- 腎臟病學 (nephrology) 是一種醫學.
- 生物标志物发现发现
背景情况:
- 矩阵金属蛋白酶7 (MMP-7) 是细胞外矩阵重塑和生长因子调节中的关键酶.
- 在健康的脏中,MMP-7的表达通常很低,但在急性损伤 (AKI) 和慢性病 (CKD) 期间显著增加.
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