法国脏流行病学和信息网络成立20周年
Isabelle Kazes1, Justine Solignac2, Mathilde Lassalle3
1Service de Néphrologie, Centre Hospitalo-Universitaire de Reims, Reims, France.
Clinical kidney journal
|January 8, 2024
概括
法国脏流行病学和信息网络 (REIN) 显示,末期脏病 (ESKD) 发病率稳定. 移植等候名单的时间增加,更多的患者接受活体供体移植.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 法国脏流行病学和信息网络 (REIN) 已经活跃了20年.
- REIN作为国家数据注册处和慢性病 (CKD) 患者,科团队和卫生服务的流行病学网络.
研究的目的:
- 分析代疗法 (RRT) 发生率和流行率的10年趋势 (2012-2021年).
- 评估移植等候名单活动的变化.
- 确定RRT方式和患者获得治疗的重大转变.
主要方法:
- 利用Joinpoint回归建模来检测2012年至2021年趋势的重大变化.
- 分析了REIN注册表中的数据,REIN注册表是CKD患者的国家数据注册表.
主要成果:
- 整体治疗末期病 (ESKD) 发病率在2021年保持稳定,为每百万人口 (pmp) 169人.
- 观察到紧急透析启动率下降,同时血液透析 (HD) 的临时导管使用率增加.
- 家庭HD显示显著增长 (每年10%),而腹透析下降 (每年-1.7%). 移植等候名单的时间增加,活体捐赠者移植增加到所有移植的15%.
结论:
- 在评估医疗保健需求和法国当局规划方面,REIN数据至关重要.
- 从透析信息图表中自动检索数据可以减少数据收集负担.
- 由REIN促进的研究支持法国科,并表明该网络的前景是积极的.
相关概念视频
01:11Renal Failure: Dose Adjustments
94
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
94
01:08Renal Drug Clearance: Comparison Between Renal Excretion Methods
137
Renal clearance is a critical parameter encompassing kidney filtration, secretion, and reabsorption processes. It is calculated using a specific equation to determine the rate at which the kidneys clear a drug.
Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...
Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...
137
01:02Renal Drug Excretion: Glomerular Filtration
271
The kidney serves as the primary organ responsible for eliminating drugs and their metabolites from the body. This process, known as renal elimination, starts with glomerular filtration and results in urine formation. Each kidney houses millions of functional units called nephrons, where urine production occurs. A nephron has two main components: a renal corpuscle and a renal tubule.
Drugs gain access to the kidney via the renal artery, which progressively branches off into afferent arterioles....
Drugs gain access to the kidney via the renal artery, which progressively branches off into afferent arterioles....
271
01:27Dialysis
320
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
320
01:15Renal Drug Excretion: Overview
161
As primary excretory organs, the kidneys maintain homeostasis by removing waste substances from the bloodstream. They comprise over a million units called nephrons, which serve as the kidney's functional units.
A nephron consists of two primary structures: the renal corpuscle and the renal tubule. The renal corpuscle contains the glomerulus, a network of capillaries where the first step of renal excretion, glomerular filtration, occurs. Blood pressure forces water, ions, and small molecules...
A nephron consists of two primary structures: the renal corpuscle and the renal tubule. The renal corpuscle contains the glomerulus, a network of capillaries where the first step of renal excretion, glomerular filtration, occurs. Blood pressure forces water, ions, and small molecules...
161
01:17Factors Affecting Renal Clearance: Renal Impairment
95
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
95