连续通过皮肤和外周脊髓神经调节来修改临床完整 - - 概念验证
Elvira Mukhametova1,2,3, Alena Militskova1,2,3, Artur Biktimirov4
1Department of Neurology, Department of Biomedical Engineering, Mayo Clinic, Rochester, MN.
Mayo Clinic proceedings. Innovations, quality & outcomes
|January 8, 2024
概括
穿皮脊髓刺激 (tSCS) 和外周电刺激 (EES) 显示了脊髓损伤 (SCI) 恢复的潜力. EES 改善了自愿运动,而 tSCS 改善了平衡和姿势,两者都有助于非运动功能.
科学领域:
- 神经科学是一个神经科学.
- 康复医学 康复医学 康复医学
- 生物医学工程 生物医学工程
背景情况:
- 运动完全脊髓损伤 (SCI) 在恢复意志运动,平衡和非运动功能方面存在重大挑战.
- 传统的康复方法往往给严重SCI的个体带来有限的结果.
- 神经调节技术,包括电动脊髓刺激,正在成为潜在的治疗途径.
研究的目的:
- 评估通过皮肤进行脊髓刺激 (tSCS) 和外周电刺激 (EES) 对运动,平衡和非运动功能的比较影响,对运动完整SCI的个体.
- 探索与运动训练相结合的顺序SCS和EES方法的潜力.
- 确定SCI中神经调节疗法的潜在患者选择标准.
主要方法:
- 这是一项观察性研究,涉及两名运动完全SCI的参与者.
- 顺序应用SCS和EES,每项都与8周的运动训练相结合.
- 用电生理学评估,电肌图 (EMG) 和动力学评估来评估神经连接和功能恢复.
主要成果:
- 穿皮脊髓刺激 (tSCS) 促进了自愿运动的初步改善,这对于启动康复至关重要.
- 与SCS相比,外周电刺激 (EES) 显示了自愿运动的立即改善.
- 在改善平衡和姿势方面,思维神经系统显得更有效,而思维神经系统和思维神经系统则在运动训练期间促进了非运动功能的持续改善.
结论:
- 在SCS和EES的神经恢复效果中存在显著差异,支持它们的顺序应用作为SCI的潜在疗法.
- 这种结合神经调节和康复的方法可能有助于选择可接受治疗的SCI患者,并尽早开始治疗,特别是对于运动完整的SCI.
- 需要进行进一步的研究,以优化顺序的 tSCS 和 EES 协议,以最大限度地提高脊髓损伤的功能恢复.
更多相关视频
11:07In Vivo Intracellular Recording of Type-Identified Rat Spinal Motoneurons During Trans-Spinal Direct Current Stimulation
Published on: May 11, 2020
5.3K
06:55Author Spotlight: Advancing Spinal Cord Stimulation - Exploring the Cellular Responses of Motor Neurons Through Patch-Clamp Electrophysiology
Published on: September 8, 2023
2.6K
相关概念视频
01:33Somatosensation
The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
01:16Sensory Functions of the Skin
The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
01:29Overview of Somatic Sensory Pathways
Somatic sensory or somatosensory pathways refer to the neural pathways that carry information related to touch, pressure, pain, temperature, and proprioception from the skin, muscles, tendons, and joints to the brain. These pathways involve several stages of processing and integration of sensory information.
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...
01:28Major Somatic Sensory Pathways
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the posterior columns...