男性乳腺癌的危险因素
1Department of Surgical Oncology and Breast Surgery, Guy's Hospital London SE1 9RT, UK.
American journal of translational research
|January 8, 2024
概括
识别高风险男性乳腺癌 (MBC) 群体是具有挑战性的. 虽然BRCA2突变和克莱因菲尔特的突变.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 内分泌学 在内分泌学.
背景情况:
- 男性乳腺癌 (MBC) 诊断和风险分层构成重大挑战.
- 已知的危险因素,如肥胖和环境暴露,无法确定大型高风险队列.
- BRCA2突变和Klinefelter综合征 (KS) 是关键的遗传风险组,占MBC病例的15%.
研究的目的:
- 审查风险因素并确定男性乳腺癌高风险队列.
- 评估内分泌干预的潜力,特别是tamoxifen,在MBC管理中.
- 评估男性乳腺癌预防研究的可行性.
主要方法:
- 关于男性乳腺癌风险因素和确定高风险人群的文献综述.
- 对瘤特征的分析,并指出ER+ve瘤的高患病率 (>90%).
- 对内分泌治疗选择和对他莫西芬的患者遵守数据的审查.
主要成果:
- 没有任何一个单一的风险因素能够有效地识别出一个具有高绝对数量的MBC病例的大群.
- 携带BRCA2突变的携带者和患有Klinefelter综合征的个体是显著的高风险队列.
- 由于副作用,男性患者对他莫西芬的耐受性较差,影响了遵守.
结论:
- 目前对男性乳腺癌的风险因素的识别不足以进行大规模的预防研究.
- 虽然内分泌疗法在理论上是ER+veMBC的逻辑,但tamoxifen的副作用限制了其在男性中的使用.
- 对男性乳腺癌进行有意义的预防研究目前是不可行的,因为确定的群体的绝对病例数量很少.
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