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相关概念视频

Quantifying and Rejecting Outliers: The Grubbs Test01:02

Quantifying and Rejecting Outliers: The Grubbs Test

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Sometimes, a data set can have a recorded numerical observation that greatly  deviates from the rest of the data. Assuming that the data is normally distributed, a statistical method called the Grubbs test can be used to determine whether the observation is truly an outlier.  To perform a two-tailed Grubbs test, first, calculate the absolute difference between the outlier and the mean. Then, calculate the ratio between this difference and the standard deviation of the sample. This...
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Outliers and Influential Points01:08

Outliers and Influential Points

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An outlier is an observation of data that does not fit the rest of the data. It is sometimes called an extreme value. When you graph an outlier, it will appear not to fit the pattern of the graph. Some outliers are due to mistakes (for example, writing down 50 instead of 500), while others may indicate that something unusual is happening. Outliers are present far from the least squares line in the vertical direction. They have large "errors," where the "error" or residual is the...
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Unusual Results01:16

Unusual Results

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Unusual results are those that have a very low chance of occurring. Unusual results can be identified using probabilities and the range rule of thumb. In problems involving probability, unusual results can be observed in 2 instances – an unusually high number of successes or an unusually low number of successes.
According to the range rule of thumb, any value above or below two standard deviations, 2σ  from the mean, μ  is considered unusual.
Maximum unusual value =...
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Relative Frequency Histogram01:14

Relative Frequency Histogram

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The relative frequency depicts the proportion of data points that have each value. The frequency tells the number of data points that have each value. Like the histogram, a relative frequency histogram also has the same shape with a horizontal scale (the x-axis), but the vertical scale (the y-axis) is marked with relative frequencies (percentages of the whole) instead of actual frequencies. A relative frequency histogram is a graphical representation of a frequency distribution where the...
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Statistical Analysis: Overview01:11

Statistical Analysis: Overview

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When we take repeated measurements on the same or replicated samples, we will observe inconsistencies in the magnitude. These inconsistencies are called errors. To categorize and characterize these results and their errors, the researcher can use statistical analysis to determine the quality of the measurements and/or suitability of the methods.
One of the most commonly used statistical quantifiers is the mean, which is the ratio between the sum of the numerical values of all results and the...
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Probability Histograms01:17

Probability Histograms

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A probability histogram is a visual representation of a probability distribution. Similar a typical histogram, the probability histogram consists of contiguous (adjoining) boxes. It has both a horizontal axis and a vertical axis. The horizontal axis is labeled with what the data represents. The vertical axis is labeled with probability. Each rectangular bar in the histogram is 1 unit wide, which suggests that the area under each bar equals the probability, P(x), where x is 1, 2, 3, and so on.
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Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
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数据驱动的数学和可视化方法用于删除复合数据分析 (CoDA) 的罕见特征.

Adrian Ortiz-Velez1,2, Scott T Kelley1,2

  • 1Biological and Medical Informatics Program, San Diego State University, San Diego, CA 92182, USA.

NAR genomics and bioinformatics
|January 8, 2024
PubMed
概括

曲线切割是一种新的无监督方法,可以从稀有的生物数据中删除罕见的特征,例如元基因组学. 它使用数据驱动的断片来提高统计能力,并保留更多的特征而没有偏差.

科学领域:

  • 生物信息学是一种生物信息学.
  • 计算生物学 计算生物学
  • 数据科学数据科学数据科学

背景情况:

  • 稀有的特征表与许多罕见的特征在大型生物数据集中很常见,例如元基因组学.
  • 忽视零负载数据可能会导致统计估计偏差,并降低下游分析的力量.
  • 在组合数据中,逻辑比分析是有问题的,因为未定义的log{0}.

研究的目的:

  • 引入CurvCut,一种不受监督的,基于数据的方法,用于在稀疏的生物数据中去除罕见的特征.
  • 为处理低频特征提供强大和合理的方法,解决任意删除值的局限性.
  • 为了使研究人员能够自信地识别和应用功能删除切断,最大限度地提高功能保留和分析能力.

主要方法:

  • CurvCut采用两种无监督的方法来识别特征频率分布中的自然断裂:曲率分析和费舍尔-詹克斯统计方法.
  • 该方法包括人类确认,以验证已识别的切断点.
  • 它旨在适用于各种生物数据类型.

主要成果:

  • CurvCut有效地识别了针对低频特征删除的特定数据的切断值,最大限度地保持特征.
  • 该方法可以快速识别这些断裂,并为用户确认生成清晰的可视化图像.

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  • 跨不同生物数据类型的应用证实了它的多功能性和有效性.
  • 结论:

    • CurvCut提供了一个数据驱动的,无监督的解决方案,用于在稀疏的生物数据集中去除罕见的特征.
    • 该方法增强了统计能力,并通过提供合理的特征删除截止值来减少下游分析中的偏差.
    • "CurvCut"有助于改进数据预处理,用于构成数据分析和其他生物信息学应用.