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连续的葡萄糖监测捕捉了袖子胃切除术后肥胖的血糖变化:一项前性队列研究
Brenda Dorcely1,2, Julie DeBermont2, Akash Gujral3
1Laboratory of Translational Obesity Research NYU Langone Health New York New York USA.
Obesity science & practice
|January 8, 2024
概括
减肥手术后的血糖变化和1小时的葡萄糖水平比HbA1c更好地表明糖尿病风险. 持续的β细胞功能障碍即使在2型糖尿病患者显著减肥后仍然存在.
科学领域:
- 代谢手术 代谢手术
- 内分泌学 在内分泌学.
- 糖尿病研究 糖尿病研究
背景情况:
- 在肥胖中评估血糖控制是具有挑战性的.
- HbA1c是实时葡萄糖失调的不敏感标记.
研究的目的:
- 评估在口服葡萄糖耐受性测试 (OGTT) 和持续葡萄糖监测 (CGM) 期间的1小时血葡萄糖 (1小时PG) 和葡萄糖变异性 (GV) 是否与HbA1c相比,更好地反映腹腔外科手术后的失糖症.
- 评估从袖子胃切除术 (SG) 减肥对2型糖尿病和没有2型糖尿病患者血糖标记物的影响.
主要方法:
- 一项前性队列研究,将10名2型糖尿病患者与11名接受SG治疗的非糖尿病患者进行比较.
- 测量包括身体重量,脂质,OGTT (葡萄糖和胰岛素) 和CGM衍生的GV (血糖外流的平均幅度 - MAGE) 在基线,手术后6周和6个月.
主要成果:
- 在6个月后,SG在两组中都导致22%的体重减轻.
- 尽管糖尿病组的HbA1c显著降低,但1-h PG和MAGE仍然升高.
- 口服处置指数,表明β细胞功能,与非糖尿病组相比,在糖尿病组中仍然较低.
结论:
- 在糖尿病患者中,高GV标志物和降低SG后的处置指数表明持续的β细胞功能障碍.
- 这些发现强调了糖尿病并发症的潜在残留风险,尽管体重减轻和HbA1c的改善.
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