表观遗传和纳米颗粒的互惠性:硬币的两面
Maryam Sanei1, Bagher Amirheidari2,3, Naghmeh Satarzadeh2,3
1Islamic Azad University, Faculty of Medicine, Mashhad branch, Mashhad, Iran.
Heliyon
|January 8, 2024
概括
纳米粒子 (NP) 在药物输送和表观遗传疗法方面表现有前途. 这篇评论探讨了NP的情况.
科学领域:
- 纳米医学是一种纳米医学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 毒理学 毒理学 毒理学
背景情况:
- 纳米粒子 (NP) 提供多维应用,特别是在药物输送中,提高生物可用性,疗效和特异性.
- 表观遗传学涉及调节基因表达的分子机制,对于理解癌症和神经疾病等疾病对环境影响至关重要.
- 表观遗传疗法显示出潜力,但由于药物毒性而面临限制.
研究的目的:
- 审查表观遗传学在纳米粒子研究中的双重作用.
- 研究表观遗传机制对纳米粒子毒性 (纳米毒性) 的影响.
- 探索纳米颗粒作为流行病药物的载体的应用.
主要方法:
- 文献综述专注于纳米技术和表观遗传学的交叉点.
- 对研究纳米毒性的表观遗传调节的研究进行分析.
- 对用于表观遗传剂的基于纳米粒子的药物递送系统的研究进行评估.
主要成果:
- 表观遗传机制在调解纳米颗粒的毒性作用方面发挥着重要作用.
- 纳米颗粒显示出作为传递表观遗传药物的有效载体的潜力,有可能克服目前的治疗局限性.
- 了解这些相互作用对于开发更安全,更有效的纳米医学和表观遗传疗法至关重要.
结论:
- 纳米粒子与表观遗传调节有着复杂的关系,影响它们的毒性和治疗潜力.
- 对纳米粒子-表观遗传相互作用的进一步研究是有必要的,以优化纳米医学和表观遗传疗法.
- 纳米颗粒有望用于针对性地输送抗疫药物,可能改善各种疾病的治疗结果.
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