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相关概念视频

Issues And Trends In Healthcare Delivery System01:29

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The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
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Drug Distribution: Volume of Distribution01:25

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The volume of distribution refers to the theoretical volume necessary to contain the entire amount of an administered drug at the same concentration observed in the blood plasma. The body's intracellular fluid compartment, which makes up two-thirds of the total body water, is contrasted with the extracellular fluid compartment—comprising plasma and interstitial fluid—that accounts for one-third. The volume of distribution can vary depending on the characteristics of the drug.
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Upon entering the systemic circulation, drugs can distribute into the interstitial and intracellular fluid of various tissue cells. This distribution is facilitated by the binding of drugs to different cellular components within tissues, which may lead to drug accumulation in specific areas. Drugs bound to tissue components serve as reservoirs that release free drugs back into the system, prolonging the drug's overall action. However, this accumulation can also result in local toxicity.
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Drug control governance involves the oversight and regulation of pharmaceuticals to ensure their safety and efficacy while preventing illegal drug use and trafficking. Regulatory bodies, including the US Food and Drug Administration (FDA) and the European Union's European Medicines Agency (EMA), play a central role in this process. These agencies evaluate the safety and efficacy of drugs before they can be marketed. They fund clinical trials and assess the benefits and risks associated with...
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Drugs predominantly attach to plasma proteins, with only a small percentage remaining unbound. The unbound portion can be calculated as one minus the bound fraction. Acidic drugs form large, inactive complexes by reversibly binding to plasma albumin, which prevents them from diffusing across biological barriers. These drug-protein complexes act as reservoirs for the drugs. As the concentration of unbound drugs decreases, these complexes quickly dissociate to release the free drug, maintaining...
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Tracking Drug-induced Changes in Receptor Post-internalization Trafficking by Colocalizational Analysis
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追踪链:基于超级账本的制药供应链 - 资源利用视角

C M Naga Sudha1, Jesu Vedha Nayahi J2

  • 1Department of Computer Technology, Anna University - MIT Campus, Chennai, Tamilnadu, India.

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概括
此摘要是机器生成的。

区块链技术提高了制药供应链的安全性和透明度. 与Hyperledger Fabric相比,Hyperledger Sawtooth提供了更高的资源利用率和更大的交易能力.

关键词:
超级账本组织织物超级账本的刀牙可以看到.制药药物 药物 制药药物资源消耗是指资源的消耗.供应链中的供应链.

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科学领域:

  • 计算机科学 计算机科学
  • 供应链管理 供应链管理
  • 信息技术 信息技术 信息技术

背景情况:

  • 区块链技术提供了一个去中心化和分布式账本系统,用于安全的点对点交易.
  • 供应链受益于通过区块链集成增强的安全性,可访问性和库存管理.
  • 供应链中的物流挑战包括数据访问和质量保证,区块链可以解决这些问题.

研究的目的:

  • 探索区块链在制药供应链中的应用,以提高可追溯性和安全性.
  • 为了比较Hyperledger Fabric和Hyperledger Sawtooth平台的供应链解决方案的性能.
  • 评估不同区块链框架的资源利用率和交易效率.

主要方法:

  • 在两个平台上开发分散的供应链概念:Hyperledger Fabric和Hyperledger Sawtooth.
  • 关于资源利用 (CPU消耗) 的Hyperledger Sawtooth和Hyperledger Fabric的比较分析.
  • 评估Hyperledger Sawtooth适用于具有分离业务逻辑的分散应用程序的适用性.

主要成果:

  • 与Hyperledger Fabric相比,Hyperledger Sawtooth显示了较低的CPU消耗.与Hyperledger Fabric相比,它显示了较低的CPU消耗.
  • 在Sawtooth中,应用程序域与核心系统的分离简化了开发和维护.
  • 在Sawtooth中资源利用率较低,促进了交易数量的增加.

结论:

  • 超级账本Sawtooth非常适合在供应链管理中开发分散的应用程序,因为它的资源效率很高.
  • 区块链集成,特别是与Hyperledger Sawtooth集成,显著提高了制药供应链可追溯性,安全性和运营效率.
  • 这些发现表明,Hyperledger Sawtooth是通过增加交易吞吐量来提高供应链性能的首选框架.