早期的生活压力调节了对儿童大脑结构和认知功能的遗传影响
Hee-Hwan Wang1, Seo-Yoon Moon2, Hyeonjin Kim3
1Department of Brain Cognitive and Science, Seoul National University, Seoul, 08825, South Korea.
Heliyon
|January 8, 2024
概括
早期的生活压力通过破坏基因-大脑通路,影响儿童的认知发展. 滥用显着加剧了这种影响,通过改变大脑结构和连接性来减少认知能力.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 发展心理学 发展心理学
背景情况:
- 众所周知,早期生活压力 (ELS) 影响大脑和认知发育,但根本机制尚未完全理解.
- 遗传因素和大脑发育对于儿童的认知能力至关重要.
研究的目的:
- 研究全基因组对儿童大脑形态和连接能力发展的影响.
- 阐明基因-大脑-认知途径以及滥用在这种关系中的调节作用.
主要方法:
- 在ABCD研究中分析了4276名儿童 (9-10岁) 的多式数据 (DNA基因型,结构/扩散MRI,神经认知测试).
- 使用多基因分数 (GPS) 估计全基因组认知功能.
- 使用形态测量和曲谱学识别认知GPS的大脑相关物.
主要成果:
- 大脑结构差异显著介导了对认知的遗传影响 (间接影响 = 0.016,P < 0.001).
- 基因与大脑之间的关系被滥用显著调节,导致认知能力下降 (中度调节指数 = -0.007).
结论:
- 提出了一种新的基因-大脑-认知模型,解释了ELS对儿童认知发展的长期负面影响.
- 滥用行为是从遗传倾向到通过大脑发育的认知结果的途径中的一个重要的调节者.
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