线粒体氧化应激,线粒体ROS风暴在长期COVID病原发生过程中
Kunwadee Noonong1,2, Moragot Chatatikun1,3, Sirirat Surinkaew1,3
1School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, Thailand.
Frontiers in immunology
|January 8, 2024
概括
这篇评论探讨了COVID-19如何影响糖尿病,并导致线粒体功能障碍,导致长期COVID. 了解这些机制是开发有效治疗持久症状的关键.
科学领域:
- 传染病的病理生理学 传染病的病理生理学
- 线粒体生物学 线粒体生物学
- 内分泌学 在内分泌学.
背景情况:
- 冠状病毒疾病2019 (COVID-19) 可能导致长期COVID,这种情况在约10%的患者中具有持续的多器官症状.
- 长期COVID的潜在机制尚不清楚,但它可能涉及线粒体失调和氧化应激.
- 长期COVID症状可以持续一年以上,甚至在病毒被清除后也会造成严重的损害和持久的并发症.
研究的目的:
- 在糖尿病的背景下审查COVID-19的病理生理学.
- 探索与COVID-19相关的细胞内反应,包括线粒体氧化应激和ROS风暴.
- 讨论线粒体调节失调作为长期COVID的潜在原因.
主要方法:
- 关于COVID-19病理生理学的现有研究的文献综述.
- 细胞内机制的分析,专注于线粒体功能和氧化应激.
- 综合目前对长期COVID病原体的理解.
主要成果:
- COVID-19涉及细胞内反应,包括线粒体氧化应激和ROS风暴.
- 长期COVID可能源于线粒体调节失调,在病毒清除后持续很长时间.
- 糖尿病似乎是COVID-19病理生理学和长期COVID发展的一个重要因素.
结论:
- 需要全面了解长期COVID阶段和病原遗传机制.
- 需要有效的药物来治疗和预防长期COVID.
- 对长期COVID中线粒体功能障碍的进一步研究将有助于未来的治疗开发.
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