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夜间的蓝光通过增强大脑衍生的神经营养因子,在底侧杏仁体中产生由压力引起的高度攻击性
Zhenlong Li1, Chau-Shoun Lee2,3, Si Chen1
1School of Basic Medical Sciences, Zhuhai Campus of Zunyi Medical University, Zhuhai, Guangdong, China.
Neurobiology of stress
|January 8, 2024
概括
夜间的蓝光暴露 (BLAN) 增加了老鼠的压力诱导的攻击性和焦虑类行为. 这是通过增强基底侧杏仁体 (BLA) 活动,特别是通过脑衍生神经营养因子 (BDNF) 信号和突触可塑性来实现的.
科学领域:
- 神经科学是一个神经科学.
- 时间生物学 时间生物学
- 行为科学 行为科学
背景情况:
- 现代社会面临着来自电子产品的夜间蓝光暴露 (BLAN) 的增加,扰乱昼夜节律.
- 以前的研究将暴露于光线与情绪变化联系起来,包括抑郁的表型,但对其他情绪的影响仍然不清楚.
- 布兰对压力引起的攻击和其潜在的神经机制的影响需要进一步研究.
研究的目的:
- 为了研究BLAN对雄性斯普拉格-道利大鼠压力引起的侵略的影响.
- 探索底侧杏仁体 (BLA) 和其相关的信号通路在调解这些效应中的作用.
- 阐明涉及来自大脑的神经营养因子 (BDNF) 和突触可塑性的特定分子机制.
主要方法:
- 进行了居民入侵者测试,以评估攻击性行为.
- 细胞外电生理学记录被用来测量BLA活性和突触可塑性 (LTP/LTD).
- 与酶相关的免疫吸收试验 (ELISA) 量化了BDNF水平,并使用分子抑制剂进行机械学研究.
主要成果:
- 暴露于BLAN导致了压力诱导的攻击性和焦虑类行为.
- 在BLA中,BLAN增强了长期增强 (LTP) 和长期抑郁 (LTD).
- BLAN增加了BDNF,成熟的BDNF和化TrkB的BLA表达;在BLA减弱的侵略中阻断了BDNF信号或可塑性.
结论:
- 暴露于BLAN导致压力引起的攻击性增加,可能由增强的BLA BDNF信号传递和突触可塑性介导.
- 针对BLA BDNF通路提供了一种潜在的治疗策略,用于管理与夜间曝光相关的情绪障碍.
- 这项研究强调了夜间蓝光对情绪调节和与压力相关的行为有重大影响.
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