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Updated: Jul 6, 2025

Fluorescence-Activated Nuclei Negative Sorting of Neurons Combined with Single Nuclei RNA Sequencing to Study the Hippocampal Neurogenic Niche
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Fluorescence-Activated Nuclei Negative Sorting of Neurons Combined with Single Nuclei RNA Sequencing to Study the Hippocampal Neurogenic Niche

Published on: October 20, 2022

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在哺乳动物大脑中,细胞类型特异的体质形积分的丰富

Eran A Mukamel1, Hanqing Liu2, M Margarita Behrens3

  • 1Department of Cognitive Science, University of California, San Diego, La Jolla, CA 92037, USA.

bioRxiv : the preprint server for biology
|January 8, 2024
PubMed
概括

阴性马赛克积体,包括整个染色体丢失或重复,发生在成年老鼠大脑中. 染色体16的三重症是丰富的,反映了唐氏综合征.

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A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations08:22

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相关概念视频

Nondisjunction01:21

Nondisjunction

Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold...
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