相关实验视频

Updated: Jul 27, 2026

Novel Atomic Force Microscopy Based Biopanning for Isolation of Morphology Specific Reagents against TDP-43 Variants in Amyotrophic Lateral Sclerosis
13:31

Novel Atomic Force Microscopy Based Biopanning for Isolation of Morphology Specific Reagents against TDP-43 Variants in Amyotrophic Lateral Sclerosis

Published on: February 12, 2015

8.8K

单核转录组图谱的轨道前皮层在肌缩性侧面硬化症与基于深度学习的解码的替代多基化机制的替代性多基化机制

Paul M McKeever, Aiden M Sababi, Raghav Sharma

    bioRxiv : the preprint server for biology
    |January 8, 2024
    PubMed
    概括

    肌缩侧面硬化症 (ALS) 和前叶退化症 (FTLD) 具有共同的疾病谱. 这项研究揭示了ALS/FTLD细胞类型的特定变化,突出了神经元的改变,并为了解这些神经退行性疾病提供了资源.

    更多相关视频

    Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae07:14

    Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae

    Published on: February 25, 2022

    6.0K
    Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches09:47

    Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

    Published on: December 15, 2023

    1.1K

    相关概念视频

    RNA Splicing01:32

    RNA Splicing

    Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
    Nucleosome Remodeling02:54

    Nucleosome Remodeling

    Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure.
    Nucleosome remodeling complex
    Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...
    Long-patch Base Excision Repair01:02

    Long-patch Base Excision Repair

    Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are: