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Updated: Jul 6, 2025

Rare Event Detection Using Error-corrected DNA and RNA Sequencing
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通过增量学习和异常检测来适应纳米孔测序基调调用模型的修改检测.

Ziyuan Wang1,2, Yinshan Fang3,2, Ziyang Liu1,4

  • 1Department of Pharmacy Practice and Science, University of Arizona, Tucson, Arizona, USA.

bioRxiv : the preprint server for biology
|January 8, 2024
PubMed
概括

本研究介绍了一种机器学习管道,用于使用纳米孔测序检测核酸修饰. 该方法实现了单分子,单核酸分辨率,用于准确的基调和修改状态确定.

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Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
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Although all next-generation methods use different technologies, they all share a set of standard features....
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