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Updated: Jul 6, 2025

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激活的PI3Kδ特异性地扰乱了小鼠Treg稳态和功能,导致免疫调节失调

Akhilesh K Singh1, Fahd Al Qureshah1,2,3, Travis Drow1

  • 1Center for Immunity and Immunotherapy, Seattle Children's Research Institute, Seattle, WA.

bioRxiv : the preprint server for biology
|January 8, 2024
PubMed
概括

在Foxp3+调节性T细胞 (Treg) 中失调的PI3Kδ信号导致慢性炎症和自身免疫. 最佳的PI3Kδ活性对于Treg平衡至关重要,这表明了治疗向潜力.

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