乙醇胺利用和细菌微分区形成在Listeria monocytogenes细胞内感染中的作用
bioRxiv : the preprint server for biology
|January 8, 2024
概括
乙胺 (EA) 的利用对Listeria monocytogenes (LMO) 细胞内生存和免疫逃避至关重要. 然而,细菌微分区 (BMC) 的形成并不总是与LMO感染期间的EA代谢有关.
科学领域:
- 微生物学 微生物学
- 细菌病原体的产生
- 细胞生物学 细胞生物学
背景情况:
- 乙醇胺 (EA) 影响人类细菌病原体的胃肠道殖民和病原性.
- EA影响了Listeria monocytogenes (LMO) 等侵入性细菌的细胞内生存和复制.
- EA利用 (eut) 基因对EA代谢至关重要,之前的研究将酶分解与LMO细胞内复制联系起来.
结论:
- 感知和利用EA对于LMO的最佳复制和宿主细胞内的免疫逃避至关重要.
- 在LMO感染肠上皮细胞时发生EUT BMC形成,但不是在大细胞中.
- 对于LMO复制的EA代谢的必要性并不总是与EUT BMCs的形成相结合.
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