高分辨率结构阐明了电压和Slo1通道LRRC26调节的基本原理
bioRxiv : the preprint server for biology
|January 8, 2024
概括
研究人员透露了Slo1通道中的电压传感器如何在激活时使用冷EM移动. 该LRRC26 (γ1) 子单元稳定了通道复合体,影响了电压门.
科学领域:
- 结构生物学 结构生物学
- 离子通道生理学 离子通道生理学
- 分子生物物理学 分子生物物理学
背景情况:
- Slo1通道对生理功能至关重要,由电压,和辅助子单元调节.
- 电压依赖性封闭和Slo1辅助子单元调制的机制尚不清楚.
结论:
- LRRC26可能会稳定非S4螺旋,促进后期电压控制的结构变化.
- 这项研究提供了关于Slo1通道电压传感和LRRC26.2调制的结构性见解.
相关概念视频
01:26Voltage-gated Ion Channels
8.2K
Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several...
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several...
8.2K
01:19Ligand-gated Ion Channels
12.4K
Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that...
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that...
12.4K