维生素B6:对2023年北欧营养建议的范围审查
Anne-Lise Bjørke-Monsen1, Per Magne Ueland2
1Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, 5021 Bergen, Norway.
维生素B6的活性形式 - - 氧5'-酸盐 (PLP) 对于许多代谢过程至关重要. 目前对维生素B6摄入量的建议可能过低,因为生化缺乏症标志物出现的PLP水平比以前认为的要高.
科学领域:
- 生物化学 生物化学
- 人类营养人类营养
- 代谢健康 代谢健康
背景情况:
- 皮里多5'-酸盐 (PLP) 是维生素B6的主要活性形式,对于160多种酶反应至关重要.
- 维生素B6在氨基酸,碳水化合物,脂质和神经递质代谢中起着至关重要的作用.
- 饮食评估,补充剂使用和分析方法的变化使准确的维生素B6摄入量估计变得复杂.
研究的目的:
- 为了评估当前推的维生素B6摄入量水平的充分性.
- 调查血PLP度与维生素B6状态的生化标志物之间的关系.
- 为了确定血PLP的确定的足够性值是否准确地反映了足够的维生素B6状态.
主要方法:
- 对血pyridoxal 5'-phosphate (PLP) 度的分析.
- 评估HK比率 (HKr) 作为维生素B6状态的代谢标记.
- 血PLP水平与已确定的足够性值和生化缺陷指标的比较.
主要成果:
- 血PLP和估计的饮食维生素B6摄入量在不同研究中存在显著差异.
- 维生素B6状态的标志物HK比率 (HKr) 开始上升,当血PLP降至100nmol/L以下时.
- 在50nmol/L以下观察到HKr的急剧增加,表明生化缺陷.
结论:
- 目前推的维生素B6摄入量可能不足.
- 血PLP度为30nmol/L,被认为是足够的,可能太低,不能表明足够的维生素B6状态.
- 生物化学标记表明,需要更高的血PLP水平来确保最佳的维生素B6状态.
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