结直肠癌化疗后的"观察和等待"方法,需要腹膜关节切除
Naruhiko Sawada1, Shumpei Mukai1, Yusuke Takehara1
1Digestive Disease Center, Showa University Northern Yokohama Hospital, 35-1, Tsuzuki-Ku, Chigasakichuo, Yokohama City, Kanagawa, 224-8503 Japan.
Indian journal of surgical oncology
|January 8, 2024
概括
新辅助化学辐射疗法 (NACRT) 随后的积极监测,如"观察和等待" (WW) 方法,为下直肠癌提供了可行的器官保护策略. 这种方法表明,与腹腔切除 (APR) 的生存率相比,治疗成本降低.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 胃肠病学 胃肠病学
背景情况:
- 新辅助化学辐射疗法 (NACRT) 是用于II-III期下直肠癌的标准手术前治疗方法.
- 腹腔切除 (APR) 是用于直肠癌的常见手术.
- 这是一个很棒的节目,这是一个很棒的节目.
- 观察和等待,等待和等待.
- (WW) 方法为部分患者提供了手术的替代方案.
研究的目的:
- 为了评估NACRT的治疗效果.
- 为了确定完全临床缓解的预测因素.
- 将APR与WW的预测和成本进行比较,并评估WW方法的实用性.
主要方法:
- 患有II-III期下直肠癌的患者接受了NACRT (52 Gy + S-1).
- 在NACRT治疗后8周,使用临床检查,内镜,CT和MRI评估治疗效果.
- 对残留瘤进行APR;对于拒绝手术的患者选择WW.
主要成果:
- 在APR和WW组之间,无病3年生存率没有显著差异.
- 与APR组相比,WW组的治疗成本较低.
- NACRT跟着WW是一个可行的器官保存策略.
结论:
- 对于需要APR的直肠癌患者,通过NACRT和积极监测可以实现器官保存.
- "观察和等待"方法是选择患者的APR的成本效益高的替代方案.
- 完整的临床缓解是成功保存器官的关键因素.
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