在零星的Koos 4 级前庭神经瘤中等待和扫描管理:一个纵向体积学研究
Sammy M Schouten1,2,3,4, Stefan Cornelissen4,5, Patrick P H J Langenhuizen4,5
1Department of Otolaryngology, Radboud University Medical Center, Nijmegen, The Netherlands.
Neuro-oncology advances
|January 8, 2024
概括
大型前庭神经瘤 (Koos 4 级 VSs) 呈现出多样化的生长. 对于某些瘤来说,等待和扫描方法是可行的,特别是当质量效应症状不存在时.
科学领域:
- 神经外科 神经外科
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
背景情况:
- 关于大前庭神经瘤 (VSs) 的自然历史研究,特别是Koo的4级,是有限的.
- 了解瘤进化对于管理这些大型VSs至关重要.
研究的目的:
- 在零星的Koo4级VS中分析体积瘤生长模式.
- 确定这些大型VS中瘤生长的潜在预测因子.
主要方法:
- 从215名库斯4级VS患者的连续MRI研究的回顾性分析,使用等待和扫描方法管理 (2001-2020年).
- 用体积测量来追踪瘤的演变,显著的生长值被定义为≥10%的体积变化.
主要成果:
- 68%的瘤显示生长,而35%显示收缩. 观察到四种不同的进化模式:持续增长 (60%),初始增长然后收缩 (7%),持续收缩 (27%) 和稳定 (5%).
- 诊断时听力良好和周围胀与瘤生长的可能性增加显著相关 (调整后HRs分别为2.21和2.22).
结论:
- 科斯4级VS表现出各种体积变化和生长模式.
- 一个初始的等待和扫描策略与密切监控是合理的管理选项,为选择的库斯4级VSs,特别是在没有显著的质量效应症状.
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