间歇性和巴雷特食道之间的关联:更新的元分析与试验顺序分析
Shaoze Ma1,2, Zhenhua Tong3, Yong He1,4
1Department of Gastroenterology, General Hospital of Northern Theater Command, Shenyang, China.
Therapeutic advances in gastroenterology
|January 8, 2024
概括
缺口是巴雷特食道 (Barrett's esophagus,BE) 的一个重要危险因素,是食道腺癌的前体. 这一发现凸显了在BE风险评估中识别沟的重要性.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 巴雷特食道 (Barrett's esophagus,BE) 是已知的食道腺癌的前体.
- 确定BE的风险因素对于早期检测和预防策略至关重要.
研究的目的:
- 系统地评估沟与发展巴雷特食道风险之间的关联.
- 使用元分析,提供对这种关联的定量估计.
主要方法:
- 进行了一项全面的元分析,包括试验顺序分析.
- 从PubMed,EMBASE和Cochrane图书馆的数据库中系统地搜索和提取数据.
- 计算了 95% 置信区间 (CI) 的聚合概率比率 (ORs) 和调整后的 ORs (aORs),并使用 Cochrane Q 测试和 I2 统计数据评估了异质性.
主要成果:
- 47项研究 (131,517名参与者) 的元分析显示,椎间板与任何长度BE (OR = 3.91) 的风险增加之间存在显著联系.
- 在调整混因子 (aOR = 3.26) 后,这种关联仍然显著.
- 缺口也与长段BE (LSBE) (OR = 10.01) 和短段BE (OR = 2.76) 的风险增加有显著联系.
结论:
- 缺口被确定为巴雷特食道的重要危险因素.
- 这种关联对于长段BE特别明显,强调了其临床重要性.
相关概念视频
Barrett Esophagus-I: Introduction
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Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
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Barrett Esophagus-II: Clinical Manifestations and Management
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Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
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Gastroesophageal Reflux Disease I: Meaning and Pathophysiology
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Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
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Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
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The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
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Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
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