微生物组和儿科发病多发性硬化症 (MS):一个系统性审查
Sanaz Mehrabani1, Mohsen Rastkar2,3, Narges Ebrahimi3,4
1Associate Professor of Pediatrics Gastroenterology, Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
AIMS neuroscience
|January 8, 2024
概括
肠道微生物群的改变与儿科多发性硬化症 (MS) 有关. 这次审查发现MS儿童的微生物群免疫平衡受损,表明其在疾病发展中的作用.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 儿科神经学 儿科神经学
背景情况:
- 肠道微生物群影响自身免疫性疾病,包括多发性硬化症 (MS).
- 了解肠道微生物群在儿科发病的MS中的作用对于疾病管理和治疗至关重要.
研究的目的:
- 系统地审查和总结有关肠道微生物群对儿科发作的MS发展的影响现有证据.
主要方法:
- 在多个数据库 (PubMed,Scopus,EMBASE,Web of Science,Google Scholar) 进行了全面的文献搜索,截至2023年1月1日.
- 两个独立的研究人员选了研究,提取了有关患者人口统计,疾病特征和便组成的数据.
- 在最终的系统性审查中,包括了四项病例控制研究.
主要成果:
- 包括的研究涉及24-68名参与者,发病时平均年龄在11.5至14.3岁之间;大多数患者是女性.
- 细菌群丰富度 (例如,Margalef指数) 和多样性 (例如,Shannon,Simpson,Faith's PD) 在儿童多发性硬化症病例中与对照组相比通常较低.
- 这些发现表明,MS儿童的肠道微生物组成和功能发生了变化.
结论:
- 系统性审查表明,在儿科发病的MS中,微生物群-免疫平衡受到破坏.
- 这些肠道微生物组的改变可能会导致儿童多发性硬化症的发病.
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