脏线粒体功能的剂量依赖调节由血管素II
Ebba Sivertsson1, Amanda Balboa1, Tomas A Schiffer2
1Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
Upsala journal of medical sciences
|January 8, 2024
概括
ангиотензин II (Ang II) 根据剂量不同,对脏线粒体产生不同的影响. 低剂量的Ang II增加了呼吸,但没有增加ATP的产生,而高剂量的Ang II则影响了两者,突出了Ang II.
科学领域:
- 线粒体生理学线粒体生理学
- 脏病理生理学脏病理生理学
- 心血管药理学心血管药理学
背景情况:
- 内缺氧是一种拟议的机制,将慢性病 (CKD) 与线粒体泄漏呼吸的增加联系在一起.
- 线粒体的氧气消耗有助于缺氧的发展.
- ангиотензин II (Ang II) 可能会以剂量依赖的方式影响线粒体功能.
研究的目的:
- 为了研究中度和高剂量的Ang II对脏线粒体功能的影响.
- 分析Ang II对线粒体泄漏呼吸道的影响.
主要方法:
- 鼠被用载体,低剂量 (400 ng/kg/min) 或高剂量 (1,000 ng/kg/min) Ang II 治疗了4周.
- 用高分辨率呼吸计评估皮层线粒体功能.
- 测量了基因表达,氧化应激 (thiobarbituric酸反应性物质) 和尿路蛋白质分泌.
主要成果:
- 低剂量的Ang II增加了线粒体的整体呼吸,而不会影响ATP生产能力;线粒体泄漏呼吸增加,而氧化应激保持不变.
- 高剂量的Ang II降低了线粒体的整体呼吸和ATP生产能力;线粒体泄漏呼吸减少,氧化应激增加.
- 高剂量的Ang II提高了血管收缩和ROS产生媒介的基因表达,同时降低了对抗途径的调节.
结论:
- ангиотензин II 对线粒体功能和脏的呼吸漏洞产生剂量依赖的作用.
- 改变的Ang II信号可以在病的背景下直接影响细胞代谢.
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