饮酒模式,酒精饮料类型和非洲食道癌症风险:全面的系统审查和元分析
Eugene Jamot Ndebia1, Gabriel Tchuente Kamsu1
1Department of Human Biology, Faculty of Health Sciences, Walter Sisulu University, Mthatha, South Africa.
Frontiers in oncology
|January 8, 2024
概括
在非洲,每天和每周的饮酒显著增加了食道癌症的风险. 传统的酒精饮料与这种癌症有很强的联系,而偶尔饮酒则与这种癌症没有明显的关联.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 在瘤学瘤学.
背景情况:
- 食道癌不成比例地影响着非洲,酒精消费是有争议的危险因素.
- 现有的研究对酒精的作用提出了相互矛盾的观点,需要在非洲背景下进行专注的审查.
研究的目的:
- 系统地审查和统计总结非洲的酒精消费模式,饮料类型和食道癌症风险之间的联系.
- 提供关于导致非洲大陆食道癌发病率的特定饮酒行为的有力证据.
主要方法:
- 从主要数据库 (Medline/PubMed,EMBASE,Web of Science,非洲在线期刊) 发表的研究进行全面的系统审查,截至2023年9月.
- 使用纽卡斯尔-太华和医疗保健研究和质量机构工具进行质量评估.
- 使用随机效应模型进行元分析,以确定聚合赔率比率 (OR) 和置信区间 (CI).
主要成果:
- 对29,026人 (11,237人患有癌症) 的元分析显示,饮酒与食道癌症风险之间存在显著的总体关联 (OR = 1.81;95% CI,1.50-2.19).
- 每日 (OR = 2.38;95% CI,1.81-3.13) 和每周 (OR = 1.94;95% CI,1.32-2.84) 的饮酒模式显示出比偶尔饮酒 (OR = 1.02;95% CI,0.81-1.29) 更强烈的关联.
- 与非传统饮料不同,传统酒精饮料的消费与风险增加有显著联系 (OR = 2.00;95% CI,1.42-2.82),而非传统饮料的消费与风险增加有显著联系.
结论:
- 每日和每周的酒精消费模式在非洲人口中显著提高食道癌症风险.
- 传统的酒精饮料是非洲食道癌的重要危险因素.
- 在本综述中,偶尔饮酒与食道癌症风险没有显著的关联.
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