严重病患COVID-19患者的维生素C缺乏,这些患者被送往重症监护室
Luis Chiscano-Camón1,2,3, Juan Carlos Ruiz-Rodriguez1,2,3, Erika P Plata-Menchaca1,2
1Intensive Care Department, Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.
Frontiers in medicine
|January 8, 2024
概括
危急病的冠状病毒传染病2019 (COVID-19) 患者在进入重症监护室 (ICU) 时经常表现出无法检测的维生素C血水平. 这些低维生素C水平在整个ICU停留期间都持续存在,这表明这些易受伤害的患者存在严重缺乏.
科学领域:
- 关键护理医学 关键护理医学
- 营养科学 营养科学
- 传染性疾病 传染性疾病
背景情况:
- 维生素C对免疫功能至关重要,重症患者经常经历氧化应激.
- 新型冠状病毒传染病2019 (COVID-19) 可以导致严重的呼吸衰竭和增加代谢需求.
- 了解COVID-19患者的维生素C状况对于优化支持性护理至关重要.
研究的目的:
- 在重症COVID-19患者中确定维生素C血动力学.
- 为了确定这种人群中维生素C缺乏的患病率和持续性.
- 为了将维生素C水平与疾病严重程度和结果相关联.
主要方法:
- 在重症监护室 (ICU) 进行了一项前性,观察性,单中心研究.
- 血维生素C度测量是在ICU入院后的1,5和10天,没有补充.
- 超高性能液体染色学 (UPLC) 用于分析维生素C水平,缺陷定义为<2 mg/L.
主要成果:
- 86%的需要呼吸支的COVID-19患者在ICU入院时有无法检测到的维生素C水平.
- 在整个研究期间,低或无法检测到的维生素C血度保持一致.
- 患者表现出严重的缺血性急性呼吸衰竭,平均SOFA分数为3和APACHE II分数为13.
结论:
- 严重的COVID-19患者经常出现严重的维生素C缺乏症.
- 这种缺陷是持久的,在ICU停留期间,如果没有补充,就不会消失.
- 对COVID-19患者补充维生素C的进一步研究是有必要的.
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