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Updated: Jul 6, 2025

Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis
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HLAEquity:检查泛等位素-HLA结合预测器中的偏差

Anja Conev1, Romanos Fasoulis1, Sarah Hall-Swan1

  • 1Department of Computer Science, Rice University, Houston, TX, USA.

iScience
|January 8, 2024
PubMed
概括

机器学习-HLA (pHLA) 预测器显示偏差. 数据集过度代表高收入人群,导致低收入人群的表现差,并挑战了"泛基因"模型概念.

关键词:
计算生物信息学是指计算机生物信息学.人类地理的人类地理免疫系统的免疫系统.机器学习 机器学习

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Conserved Binding Sites01:49

Conserved Binding Sites

Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
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