肠道微生物丰富和癌症综合征之间的因果关系:双向的门德尔随机化研究
Zexin Zhang1, Dongting Li2, Fengxi Xie3
1The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China.
Frontiers in microbiology
|January 8, 2024
概括
这项研究揭示了特定肠道细菌和癌症综合征 (CS) 之间的因果关系. 某些肠道微生物可能会防止CS,而另一些则会增加风险,需要进一步研究.
科学领域:
- 遗传学和微生物学
- 胃肠病学 胃肠病学
背景情况:
- 癌症综合征 (CS) 通常是由神经内分泌瘤引起的,活性物质会引发腹和红血等症状.
- 肠道微生物群在CS发展和进展中的确切作用在很大程度上仍未确定.
研究的目的:
- 调查肠道微生物群的丰富性与癌类综合征 (CS) 的发生之间的潜在因果关系.
- 确定可能影响发展CS的风险的特定肠道微生物种群.
主要方法:
- 使用双向门德尔随机化 (MR) 研究设计.
- 使用的单核酸多态 (SNP) 与肠道微生物群的丰富性和CS相关,来源于GWAS数据.
- 应用了逆方差加权 (IVW) 方法,并补充了MR-Egger,加权中位数和加权模型,以获得可靠的因果推理.
- 进行了异质性,性,灵敏性 (Leave-One-Out) 和反向因果关系 (Steiger) 测试,以确保发现的有效性.
主要成果:
- 确定了六种肠道微生物群,与CS有显著的因果关系.
- 该属的*Anaerofilum*证明了对CS的保护作用 (IVW OR:0.3606,p=0.0175).
- 相反, *Coriobacteriaceae*家族, *Enterorhabdus*, *Ruminiclostridium6*, *Veillonella* 和 *Holdemanella* 属与CS.的风险增加有关.
- 在CS和已识别的微生物种群之间没有发现反向因果关系的证据.
结论:
- 在六种特定的肠道微生物种群和癌症综合征之间建立了因果关系.
- 这些发现突出了CS干预的潜在微生物目标.
- 建议通过随机对照试验进一步验证以确认这些关联.
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