摄入量和各种类型心血管疾病的风险:孟德尔的随机化研究
Qingming Fu1, Rumeng Chen2, Yining Ding3
1School of Stomatology, Changsha Medical University, Changsha, China.
Frontiers in nutrition
|January 8, 2024
概括
高摄入量,以尿中的/肌素比率来表示,因果性地增加了七种心血管疾病 (CVD) 的风险. 这一发现支持限制用于预防心血管疾病的消耗.
科学领域:
- 心血管科学 心血管科学
- 营养流行病学 营养流行病学
- 遗传流行病学遗传流行病学
背景情况:
- 关于摄入量和心血管疾病 (CVD) 的观察性研究产生了相互矛盾的结果.
- 使用孟德尔的随机化 (MR) 方法来研究摄入量与心血管疾病之间的因果关系.
- 尿中的/肌因比 (UNa/UCr) 作为摄入量的代理.
研究的目的:
- 确定摄入量与50种不同的心血管疾病 (CVD) 之间的因果关系.
- 利用遗传数据对对心血管疾病风险的影响进行可靠的评估.
- 为摄入指南提供基于证据的建议.
主要方法:
- 进行了两样本的门德尔随机化 (MR) 分析.
- 利用了来自英国生物库的UNa/UCr和来自FinnGen的50种心血管疾病的全基因组关联研究 (GWAS) 数据.
- 对于多重比较的纠正,应用了5%的错误发现率 (FDR).
主要成果:
- 基因预测的UNa/UCr与七种心血管疾病有显著的积极关联.
- 具体来说,发现了与冠状动脉样硬化,动脉/动脉/毛细血管疾病,硬心血管疾病,缺血性心脏病,主要冠状动脉疾病事件,心肌梗塞和外周动脉疾病的关联.
- 反变量加权,MR-Egger和加权中位数方法产生了一致的结果,没有发现显著的异质性或水平变性.
结论:
- 在尿/肌素比率和多重心血管疾病之间存在显著的积极因果关系.
- 这些发现为推限制摄入量作为心血管疾病预防策略提供了强有力的理论基础.
- 这项研究加强了饮食管理在心血管健康公共卫生倡议中的重要性.
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