青少年肥胖症和ANGPTL8:与高灵敏度C反应蛋白,瘦素和化学素相关
Maha M Hammad1, Arshad M Channanath2, Mohamed Abu-Farha3
1Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
Frontiers in endocrinology
|January 8, 2024
概括
在肥胖的阿拉伯青少年中,血管类蛋白8 (ANGPTL8) 的血水平显著更高. 增加的ANGPTL8与该人群中患超重和肥胖的可能性更高有关.
科学领域:
- 代谢研究的研究.
- 儿科内分泌学 儿科内分泌学
- 肥胖科学 肥胖科学
背景情况:
- 血管类蛋白 (ANGPTLs) 是代谢功能的关键调节者.
- 之前的研究表明,肥胖成年人ANGPTL8升高,但缺乏关于青少年的数据,特别是在像科威特阿拉伯人这样快速过渡的人口中.
研究的目的:
- 在科威特阿拉伯青年中研究ANGPTL8在青少年肥胖中的作用和水平.
- 评估ANGPTL8作为儿童肥胖的潜在早期生物标志物.
主要方法:
- 一项涉及452名来自科威特的阿拉伯青少年 (年龄11-14岁) 的横截面研究.
- 用BMI-for-age增长图表将参与者分为正常体重,超重和肥胖类别.
- 使用ELISA和基于珠子的多重测试测量血ANGPTL8,hsCRP,瘦素和化学素.
主要成果:
- 超重和肥胖青少年的血ANGPTL8水平明显高于正常体重的同龄人,不论性别.
- 较高的ANGPTL8水平与肥胖的可能性增加了7倍,超重的可能性增加了2倍.
- ANGPTL8水平与hsCRP,瘦素和化学素有显著的相关性,并显示肥胖的预后值 (AUC=0.703).
结论:
- 在阿拉伯青少年中,增加的ANGPTL8水平与增加的BMI-for-age z-score相关,并与已确定的肥胖和炎症标志物有关.
- ANGPTL8可能在儿童和青少年肥胖的早期发展中发挥作用.
- ANGPTL8显示为这个人口群中青少年肥胖的早期预测标志物.
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