轻度低温和氧化诱导的麻醉症对手动和认知表现的联合影响
Maaike I Moes1, Antonis Elia1, Mikael Gennser1
1Division of Environmental Physiology, Swedish Aerospace Physiology Center, KTH Royal Institute of Technology, Stockholm, Sweden.
概括
潜水员面临着由寒冷和惰性气体麻醉引起的认知衰退. 这项研究表明,氧化 (N2O) 麻醉在长时间浸泡在冷水中持续恶化认知功能.
科学领域:
- 环境生理学环境生理学
- 人类表现的人类表现.
- 神经科学是一个神经科学.
背景情况:
- 潜水员容易因冷和惰性气体麻醉症而受到认知障碍.
- 之前的研究已经孤立地对这些因素进行了评估,并且持续时间很短.
- 长时间暴露于寒冷和麻醉对认知的相互作用影响仍未得到充分研究.
研究的目的:
- 研究轻度低温和氧化 (N2O) 麻醉对认知功能的联合影响.
- 在长期,代的冷水浸泡 (CWI) 期间评估认知表现,有或没有N2O暴露.
- 为了确定麻醉是否会加剧感冒引起的认知缺陷.
主要方法:
- 14名男性参加了两个12小时的会议,每次有3次120分钟的CWI (20°C).
- 在CWIs期间,受试者以单盲的方式吸入正常空气或含有30%N2O的normoxic气体混合物.
- 认知功能使用手指灵巧测试和Windows (WinSCAT) 空间飞行认知评估工具进行评估.
主要成果:
- 仅轻度低温就会影响短期记忆和学习,主要是在第一次CWI期间.
- 氧化 (N2O) 在所有CWI中显著损害了短期记忆和学习.
- N2O持续地影响了手指的灵敏度,注意力,集中力,工作记忆和空间处理.
结论:
- 由N2O诱导的惰性气体麻醉,在长时间暴露在寒冷中,持续加剧基本和更高阶的认知能力.
- 这些发现强调了环境压力因素对潜水员认知表现的重大风险.
- 这项研究强调了在具有挑战性的水下环境中减轻认知障碍的战略的必要性.
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