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Updated: Jul 6, 2025

Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology
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Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology

Published on: March 31, 2022

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针对HSP90-CDC37蛋白质-蛋白质相互作用的抑制剂的合理设计

Qiuyue Zhang1,2, Ling Yan1,2, Yuxuan Zhang1,2

  • 1State Key Laboratory of Natural Medicines & Jiangsu Key Laboratory of Drug Design & Optimization, China Pharmaceutical University, Nanjing, 210009, China.

Future medicinal chemistry
|January 8, 2024
PubMed
概括

研究人员开发了一种新型的抑制剂,针对HSP90-CDC37蛋白质-蛋白质相互作用 (PPI),对癌症至关重要. 这一新战略为开发向癌症治疗提供了一种快速有效的方法.

关键词:
HSP90CDC37 PPI 抑制剂的使用伪基质是一种伪基质.合理的设计理性的设计.顺序对齐的顺序对齐

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Protein-protein Interfaces02:04

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Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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