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胸腔液碳水化合物抗原72-4和恶性胸腔溢液:一个诊断测试准确性研究

Xi-Shan Cao^1,2, Li Yan^2,3, Ting-Wang Jiang⁴

¹Department of Laboratory Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.

Therapeutic advances in respiratory disease

|January 8, 2024

概括

肺液中的碳水化合物抗原72-4 (CA72-4) 有助于诊断恶性肺 (MPE). 这项研究表明,在未诊断的病例中,CA72-4有效地区分了MPE与良性流 (BPE).

科学领域:

在瘤学瘤学.
肺部病理学肺部病理学
诊断医学诊断医学诊断医学

背景情况:

恶性流 (MPE) 的预后不好,需要准确及时诊断.
碳水化合物抗原72-4 (CA72-4) 被认为是MPE诊断的潜在生物标志物.

研究的目的:

为了评估肺部液CA72-4的诊断准确性,用于识别MPE.
评估CA72-4在区分MPE与良性肺溢液 (BPE) 中的临床实用性.

主要方法:

一项前性双盲诊断准确性研究,涉及患有未被诊断的多流液的参与者.
用电化学发光技术测量了多液中的CA72-4水平.
通过接收器操作特征 (ROC) 曲线和决策曲线分析 (DCA) 评估诊断准确性.

主要成果:

与BPE患者相比,MPE患者在两个队列中表现出明显更高的肺部液CA72-4水平.
在Hohhot队列中,CA72-4在8U/mL切线时达到0.46的灵敏度,1.00的特异性和0.79的AUC.
在长沙队列中,CA72-4的敏感度为0.27,特异性为0.94,AUC为0.86. 对于CA72-4的确定,DCA表示了高净利.

结论:

胸腔液CA72-4是区分MPE和BPE在未诊断出血患者中的一个有价值的工具.
CA72-4显示出作为辅助诊断标记物的前景,特别是在阴性细胞学 (AUC 0.67) 的病例中.

关键词:

在 CA72-4 CA72-4 中.诊断诊断诊断诊断诊断诊断恶性多叶膜溢出恶性多叶膜溢出灵敏度灵敏度灵敏度是指灵敏度是指灵敏度.特殊性的特异性

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