在临床样本中,多种催眠处方的患病率和相关性
Bhanu Prakash Kolla1,2, Meghna P Mansukhani2, Subhajit Chakravorty3
1Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota.
概括
多重催眠处方很常见,影响10%的患者. 这种做法与情绪障碍,焦虑,慢性疼痛和睡眠问题的增加率有关,这表明需要个性化治疗方法.
科学领域:
- 睡眠医学 睡眠医学
- 临床药理学 临床药理学
- 精神病学是一个精神病学.
背景情况:
- 在临床实践中经常观察到多种催眠处方.
- 了解多种催眠处方的特征和关联对于患者护理至关重要.
研究的目的:
- 为了调查多重催眠处方的流行情况.
- 为了确定与催眠使用相关的临床和人口因素.
- 使用全现象关联研究 (PheWAS) 探索多种催眠处方和各种诊断之间的关联.
主要方法:
- 分析了梅奥诊所生物库52,940名成年参与者的电子健康记录 (EHR).
- 没有,单次或多次 (≥2) 催眠处方的参与者之间的人口和临床特征的比较.
- 基于表型的,全现象关联研究 (PheWAS) 以确定与多种催眠处方相关的诊断,调整混因素.
主要成果:
- 33%的参与者接受了至少一种催眠药,10%接受了多种催眠药.
- 催眠使用者更有可能是老年人,女性,白人,具有更长的电子健康记录和更多的诊断.
- 多重催眠处方与年轻的年龄,女性性别,更长的EHR,更多的诊断,以及情绪障碍,焦虑障碍,自杀念头,不安腿综合征和慢性疼痛的更高率有关.
结论:
- 多重催眠处方是常见的,并且与精神病,慢性疼痛和与睡眠有关的运动障碍的更高发病率有关.
- 这些发现凸显了对潜在遗传因素的进一步研究的需要,以实现个性化的失眠治疗策略.
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