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Updated: Jul 29, 2026

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
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[使用人类单细胞THP-1细胞和Bacillus Calmette-Guerin细胞构建的3维结核球形模型的表征]

J Guo1,2, Y Qiu1,2, C Hu1,2

  • 1School of Biomedical Engineering, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

Nan fang yi ke da xue xue bao = Journal of Southern Medical University
|January 8, 2024
PubMed
概括

开发了一种新的3D结核球形模型,以研究颗粒瘤的形成. 这种模型有效地模拟了结核病环境,并有助于评估抗结核药物的有效性,显示了利芬素.

关键词:
毒品的透 毒品的透微观环境是一个微观环境.结核病球形模型结核性颗粒瘤的发生.

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Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...