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Updated: Jul 6, 2025

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在神经母细胞瘤中对脑转移进行naxitamab的部分反应

Chinyere Onyeukwu¹, Autumn Williams², Brian Seyboth³

¹Department of Hematology/Oncology, Rush University Medical Center.

Journal of pediatric hematology/oncology

|January 8, 2024

概括

纳西他马布 (NAX) 在高风险神经母细胞瘤 (NBL) 中对大脑转移有意想不到的疗效. 这种单克隆抗体治疗,通常用于骨病,为患有中枢神经系统参与的儿科癌症患者提供了新的希望.

科学领域:

儿科瘤学儿科瘤学
神经科学是一个神经科学.
免疫治疗是一种免疫疗法.

背景情况:

神经母细胞瘤 (NBL) 是一种高风险的儿科癌症,结果不佳,特别是在MYCN放大的情况下.
目前用于复发的NBL的治疗方法,包括naxitamab (NAX),已被批准用于骨或骨髓疾病.
纳克西塔马布准在NBL中过度表达的抗disialoganglioside,但其穿越血脑屏障的能力是有限的.

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