慢性,非致病性母体免疫激活对后代产后肌肉和免疫结果的影响
Erin E Bryan1, Nick M Bode1, Xuenan Chen1
1Department of Animal Sciences, University of Illinois Urbana-Champaign, Urbana, IL 61802, USA.
Journal of animal science
|January 8, 2024
概括
孕产妇的炎症没有显著影响小猪的肌肉发育或幼存活率. 然而,来自炎症母亲的后代对产后挑战表现出抑制的先天免疫反应.
科学领域:
- 动物科学动物科学
- 免疫学 免疫学 免疫学
- 发展生物学 发展生物学
背景情况:
- 孕期母亲的炎症会影响后代的发育和免疫功能.
- 了解这些影响对于改善牲畜健康和生产率至关重要.
研究的目的:
- 研究母体免疫激活对猪后代肌肉发育的影响.
- 评估母体炎症对小猪产后天生的免疫反应的影响.
主要方法:
- 在怀孕期间暴露于脂聚糖化物 (LPS) 或盐水的孕妇 (猪) 进行了受控研究.
- 测量母亲和后代的炎症标志物 (TNF-α,IL-6,IL-1β).
- 评估后代的生长,肌肉特征和对产后LPS挑战的免疫反应.
主要成果:
- 孕产妇的炎症导致小猪的出生和断奶体重较小,并减少半肌肉的大小.
- 尽管有一些肌肉纤维的差异,总体肌肉和器官的重量没有显著改变.
- 与对照人群相比,炎症母亲的后代对产后免疫挑战表现出抑制的TNF-α反应.
结论:
- 在猪中,孕期孕产妇免疫激活不会显著改变肌肉发育.
- 然而,当出生后受到挑战时,它会导致后代的先天免疫反应减弱.
- 这些发现突出了产前炎症的潜在的长期免疫编程影响.
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