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Updated: Jul 6, 2025

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
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低价值Al/Zn异构金属的合成和模块反应,由常见单胺胺基支持

Fabian Dankert1, Eva Hevia1

  • 1Department für Chemie, Biochemie und Pharmazie, Universität Bern, Freiestraße 3, Bern, 3012, Switzerland.

Chemistry (Weinheim an der Bergstrasse, Germany)
|January 8, 2024
PubMed
概括

新的-双金属复合物被合成和研究. 配体选择影响反应性,其中一个复合体通过其-键显示小分子的独特激活.

关键词:
合金 合金 是一种氨基酸氨基化物 氨基酸氨基化物双金属合作 双金属合作小分子激活方式可以在中找到.

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Amides to Amines: LiAlH4 Reduction01:20

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As shown below, the mechanism involves three steps. Firstly, the hydride ion acting as a nucleophile attacks the nitrile carbon to form an anion. In the second step, a second equivalent of the hydride ion attacks the anion to...
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Direct alkylation of ammonia produces polyalkylated amines, along with a quaternary ammonium salt. To exclusively prepare primary amines, the azide synthesis method can be used.
Azide ions act as good nucleophiles and react with unhindered alkyl halides to form alkyl azides. Alkyl azides do not participate in further nucleophilic substitution reactions, thereby eliminating the chances of polyalkylated products. Alkyl azides are reduced by hydride-based reducing agents, like lithium aluminum...
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