IL-12/IL-23轴的多态性与冠状动脉心脏病有关
Jiangtao Dong1,2,3,4, Qianwen Chen1,2,3,5, Tian Xie1,2,3
1Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Journal of cellular and molecular medicine
|January 8, 2024
概括
一种常见的IL12B基因变异,特别是rs2853694,与冠状动脉心脏病 (CHD) 和其亚型有显著联系. 这一发现表明IL-12p40可能是动脉样硬化相关心脏病的治疗点.
科学领域:
- 免疫遗传学 免疫遗传学
- 心血管疾病研究研究
- 动脉样硬化病原体的产生
背景情况:
- 介质素-12B (IL12B) 编码了IL-12和IL-23的共享p40子单元 (IL-12p40),这些细胞因子与免疫功能和动脉样硬化有关.
- 在本研究之前,IL12B在冠心病 (CHD) 发展中的特定作用尚不清楚.
研究的目的:
- 研究IL12B基因中单核酸多态 (SNPs) 与汉族中国人中心脏病风险之间的关联.
- 探索IL12BSNP与心血管疾病的严重程度和临床亚型之间的关系.
主要方法:
- 一项涉及1824名心血管疾病患者和2784名对照者的病例控制研究.
- 使用后勤和多重线性回归分析对五个IL12BSNP (rs1003199,rs3212219,rs2569254,rs2853694,rs3212227) 进行基因型鉴定.
- 用ELISA测量血IL12B度以评估功能相关性.
主要成果:
- 在IL12B SNP rs2853694和心脏病风险之间发现了显著的关联 (p_adj = 2.075 × 10^-5).
- rs2853694显示了与不同性别,发病年龄 (早期/晚期) 和临床分类 (临床/解剖学) 之间与心血管疾病的显著关联.
- 在心脏病患者中,rs2853694基因型携带者 (TT vs GT) 之间,血清IL12B水平有显著差异.
结论:
- 一种常见的IL12B变体 (rs2853694) 与心脏病及其子组有显著的关联.
- 作为IL-12和IL-23的共享子单元,IL-12p40可能在IL-12/IL-23轴介导的动脉样硬化中发挥关键作用.
- IL12B代表了冠心病的潜在治疗标.
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