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反意义寡核酸介导IGFBPs的下调 增强IGF-1信号传递

Alper Yavas1, Maaike van Putten1, Annemieke Aartsma-Rus1

  • 1Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.

Journal of neuromuscular diseases
|January 8, 2024
PubMed
概括

针对IGF结合蛋白的反感性寡核酸体在体外显示出增强胰岛素样生长因子-1 (IGF-1) 信号传递的潜力. 然而,这种方法未能在体内显示出有效性,突出了需要改进的输送方法.

关键词:
杜申尼肌肉发育不良症是什么结合IGF的蛋白质可以与IGF结合.胰岛素类生长因子-1反感的寡核化物.突出跳过的突出跳过

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