在患有胸前大动脉动脉瘤和MYH11变异的患者中,稳定的甲状腺癌
Vahab Fatourechi1, Amy A Swanson2, Robert A Lee3
1Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, Minnesota, USA.
Endocrinology, diabetes & metabolism case reports
|January 8, 2024
概括
这项案例研究强调了一名患有乳头甲状腺癌和MYH11基因变异的患者,他经历了57年的惰性疾病过程. 部转移的长期稳定性表明,在某些特定情况下,观察可能是合适的.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 心血管医学 心血管医学
背景情况:
- 乳头甲状腺癌可以呈现惰的部转移.
- 家庭胸前动脉动脉瘤和解剖 (FTAAD) 是一种重要的血管疾病.
- MYH11基因与血管光滑肌细胞功能和大动脉疾病有关.
研究的目的:
- 在患有FTAAD和MYH11基因变异的患者中报告一种单一的乳头甲状腺癌病例,该病例具有无效的部转移.
- 讨论长期疾病稳定性对治疗晚期甲状腺癌的影响.
- 突出MYH11变异与复杂的临床表现之间的潜在关联.
主要方法:
- 病例报告详细介绍患者的病史,治疗和随访情况.
- 对跨越五十年的临床过程的审查.
- 基因分析确定MYH11基因变异.
主要成果:
- 一名患有乳头甲状腺癌,FTAAD和MYH11变异的男性患者在14岁初始部分切除后经历了57年的稳定,化的部转移.
- 患者在整个治疗过程中一直接受抑制性甲状腺激素治疗.
- 在多次随访期间,转移性疾病的稳定性得到证实.
结论:
- 带有子转移的乳头甲状腺癌可能表现出长期的惰行为,这表明观察可能是特定情况下的可行策略,具有记录的长期稳定性.
- 这是首次报告将MYH11基因变异与胸前动脉动脉瘤联系在一起的病例,该病例发生在患有惰性转移性乳头甲状腺癌的患者身上.
- 对甲状腺癌中MYH11基因变异的进一步研究是有必要的,以了解它们在疾病进展和呈现中的作用.
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