前列腺癌中与瘤相关的巨细胞和PD-L1:这可能是解锁免疫治疗疗效的关键
Jinhuan Wang1,2, Wenqi Wu1, Tian Yuan1
1Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
Aging
|January 8, 2024
概括
与瘤相关的巨细胞 (TAMs),特别是M2-TAMs,和PD-L1表达与前列腺癌 (PCa) 有关. 这些高水平表明PCa患者的预后较差,没有复发的生存时间较短.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症研究 癌症研究
背景情况:
- 前列腺癌 (PCa) 的特征是作为一种
- 寒冷的冷冷的冷冷的冷冷的冷冷的
- 有限免疫疗法反应的瘤.
- 瘤相关巨细胞 (TAMs) 和PD-L1是关键的免疫调节剂,但它们在PCa中的相互作用尚未得到充分理解.
研究的目的:
- 调查TAM透和前列腺癌中PD-L1表达之间的关联.
- 确定TAMs和PD-L1在PCa进展和复发中的预后意义.
主要方法:
- 使用生物信息学和免疫组织化学分析95个PCa组织样本和公共数据集.
- 对TAM亚型 (CD68+,CD163+) 和PD-L1表达的评估.
- 与格里森得分的相关性分析,风险分层和生化无复发生存率.
主要成果:
- 与正常组织相比,PCa组织中CD68+和CD163+TAMs (M2-TAMs) 显著升高.
- CD163+ TAM 透与更高的格利森分数和风险分层相关.
- 提升的PD-L1表达与增加的CD163+TAM透和更短的无复发生存时间显著相关.
结论:
- CD163+ TAMs与PCa中的PD-L1表达密切相关,作为潜在的预后生物标志物.
- 高M2-TAM透和PD-L1过度表达可能导致PCa中的免疫逃逸,对预后产生负面影响.
相关概念视频
Tumor Immunotherapy
527
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
527
The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K


