健康国家公用事业与虚假阳性癌症查结果相关
Louis S Matza1, Timothy A Howell2, Eric T Fung3
1Evidera, Bethesda, MD, USA. louis.matza@evidera.com.
PharmacoEconomics - open
|January 8, 2024
概括
假阳性癌症查结果导致健康效益显著下降,影响生活质量. 了解这种无用性对于评估新的癌症检测方法至关重要.
科学领域:
- 卫生经济学 卫生经济学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 早期癌症检测可以改善患者的治疗结果和生存率.
- 新的多种癌症早期检测测试正在出现.
- 经济评估需要健康状态实用值.
研究的目的:
- 量化与癌症查假阳性结果相关的无用性.
- 为癌症查策略的成本效益分析提供信息.
主要方法:
- 与英国普通人口参与者进行了复合时间权衡访谈.
- 参与者评估了健康状况,描述了真负和假阳性癌症查情景.
- 不实用性被计算为真负和假正状态在1年的时间范围内之间的实用性差异.
主要成果:
- 真负结果的平均效用值为0.958.
- 假阳性结果产生了从0.847到0.932.9的公用事业费用.
- 虚假阳性的失用率从 -0.031 到 -0.111 的质量调整寿命年下降.
结论:
- 所有虚假阳性癌症查结果都导致了可测量的健康效益下降.
- 更高的无用性与侵入性手术,长时间的不确定性和感知到的癌症严重程度有关.
- 这些实用性估计对于癌症查计划的经济建模具有价值.
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