双重任务步行训练改善了帕金森病的认知和休息状态功能连接,具有姿势不稳定性和步行障碍
Michela Leocadi1,2, Elisa Canu1, Elisabetta Sarasso1,2,3
1Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Via Olgettina, 60, 20132, Milan, Italy.
Journal of neurology
|January 8, 2024
概括
双任务步行和平衡训练,特别是动作观察和运动图像,改善了帕金森病患者的认知能力. 这种特殊的训练也导致了有益的脑网络功能连接变化.
科学领域:
- 神经科学是一个神经科学.
- 康复医学 康复医学 康复医学
- 运动障碍 运动障碍
背景情况:
- 帕金森病 (PD) 与姿势不稳定和步态障碍 (PIGD) 显著影响日常功能.
- 认知缺陷,特别是执行注意力功能,在PD-PIGD中很常见.
- 双任务训练是解决步态和认知障碍的一个有希望的方法.
研究的目的:
- 评估双任务步行/平衡训练与动作观察训练 (AOT) 和运动影像 (MI) 结合对认知表现的有效性.
- 研究这种综合训练对PD-PIGD患者静止状态大脑功能连接 (FC) 的影响.
- 将这些效应与单独的双重任务培训进行比较.
主要方法:
- 这是一项随机对照试验,涉及21名PD-PIGD患者.
- 两个组:双任务+AOT-MI和双任务 (控制).
- 在训练前后进行认知和休息状态fMRI评估的6周干预.
主要成果:
- 两组人都表现出更好的执行注意力 (双重任务) 技能.
- 双任务+AOT-MI组在前侧突出网络 (aSAL) 中表现出增加的FC,在前部默认模式网络 (aDMN) 中表现出降低的FC.
- 双任务+AOT-MI组的aDMN FC降低与增强的双任务性能相关.
结论:
- 双任务步行/平衡训练,有或没有AOT-MI,可以增强PD-PIGD患者的认知功能和大脑重组.
- 双重任务+AOT-MI训练专门调节额外运动大脑网络,与提高双重任务能力相关联.
- 这表明AOT-MI是PD-PIGD康复的宝贵补充.
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