相关实验视频

Updated: Jul 6, 2025

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure

Published on: August 11, 2017

主要与获得的表皮生长因子受体Thr790Met突变非小细胞肺癌:临床特征和预后

Siqi Zhou^1,2, Guoxin Cai^2,3, Xue Meng²

¹Department of Oncology, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, Shandong, China.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

|January 8, 2024

概括

与获得的T790M相比,EGFR中的初级T790M突变与更糟糕的预后和独特的分子特征有关. 获得的T790M突变显示出更好的存活率和治疗反应,特别是EGFR共突变.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学遗传学是一个

背景情况:

表皮生长因子受体 (EGFR) 突变是非小细胞肺癌 (NSCLC) 的关键驱动因素.
这种T790M突变赋予了对第一代和第二代EGFR氨酸激酶抑制剂 (TKI) 的耐药性.
在治疗策略中,区分原发性和获得性T790M突变至关重要.

研究的目的:

研究原发性EGFR T790M突变对临床特征的影响.
评估NSCLC患者中原发性和获得的T790M突变的预后意义.
分析EGFR突变与治疗结果之间的关联.

主要方法:

临床病理特征和生存数据的回顾性分析.
在患有原发性和获得T790M突变的患者之间比较突变概况和临床结果.
对具有与其他EGFR突变共存的初级T790M突变患者的子组分析.

主要成果:

主要的T790M突变与同时发生的L858R (60.53%) 和19del (18.42%) 突变以及大脑转移 (21.05%) 的更高率有关.
获得的T790M突变显示共突变和大脑转移的频率显著不同 (p <0.05).
获得T790M突变的患者的整体存活时间显着更长 (48个月vs. 33个月,p = 0.030) 并且在存在L858R共同突变时,第三代EGFR-TKIs治疗失败的时间有所改善 (17个月vs. 9个月,p = 0.009).

结论:

初级T790M突变与与获得的T790M突变相比,具有不同的分子概况和较差的预后.
获得的T790M突变预示着更好的预后和对第三代EGFR-TKI的改善反应.
EGFR共同突变的存在可能会影响对第三代EGFR-TKI的耐药性.

关键词:

共同突变是一种共同突变.在NSCLCLC中,我们可以看到.主要EGFR T790M突变发生的原因幸存的生存方式有针对性的治疗.

更多相关视频

Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib

Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib

Published on: June 26, 2019

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

相关概念视频

Mitogens and the Cell Cycle

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...