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在活体脏捐赠后,身体中部脂肪分布和脏功能
Lisa B Westenberg1,2, Robert A Pol2, Jessica van der Weijden1
1Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Clinical journal of the American Society of Nephrology : CJASN
|January 8, 2024
概括
较高的体重指数 (BMI) 和腰围 (WC) 与活着的脏捐赠者长期减少功能有关. 这些措施可能比单独的BMI更好地评估脏捐赠的风险.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植 移植 移植 移植
- 肥胖医学 肥胖医学
背景情况:
- 目前的脏捐赠者查往往是高体重指数 (BMI) 的禁忌.
- 新出现的证据表明,中央脂肪度的测量可以更好地预测风险.
- 这项研究调查了BMI,中央脂肪和脏切除术后长期功能之间的关联.
研究的目的:
- 为了确定BMI和身体中部脂肪分布 (腰围[WC],腰与身高的比率[WHtR]) 是否与活体脏捐赠后的长期功能相关.
- 测试一个假设,即更高的BMI,WC和WHtR与捐赠后功能下降有关.
主要方法:
- 在查期间,活着的脏捐赠者被评估BMI,WC和WHtR.
- 捐赠后的功能通过测量膜过率 (mGFR) 在3个月,5年,10年后进行评估.
- 多变量线性回归和线性混合模型分析了人体测量和功能 (mGFR,eGFR) 之间的关联.
主要成果:
- 在所有随访点 (3个月,5年,10年) 上,更高的先性BMI独立地与更低的mGFR相关.
- 增加的WC也与长期捐赠后的mGFR降低有显著联系.
- 在男性捐赠者中,BMI和WC都显示出与捐赠后估计的膜过率 (eGFR) 的变化有显著的负相关性.
结论:
- 增加的BMI和WC独立地与活着的脏捐赠者的长期功能下降有关.
- 这些发现表明,在脏捐赠者的风险评估中,除了BMI外,还应该考虑中央脂肪测量.
- 进一步的研究可能会根据人体组成和长期脏结果来完善供体选择标准.
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