早期Tecovirimat治疗艾滋病毒感染者中Mpox疾病的治疗方法
Bruce Aldred1,2, Robert H Lyles3, Jane Y Scott1
1Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
JAMA internal medicine
|January 8, 2024
概括
早期的特科维里马治疗显著减少了艾滋病毒 (PWH) 感染者的mopox疾病进展. 这项研究支持在怀疑mopox的PWH中立即启动tecovirimat,特别是那些症状严重的人.
科学领域:
- 传染性疾病 传染性疾病
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 在2022年疫情期间,Tecovirimat被广泛用于艾滋病毒感染者 (PWH) 的mpox,尽管人类有效性数据有限.
- 具有较低CD4+T细胞计数或严重的mopox的PWH特别有可能接受tecovirimat.
研究的目的:
- 评估早期的特科维里马特治疗 (症状发病后7天内) 是否可以减少PWH中mopox疾病的进展.
- 确定与PWH中mopox疾病进展相关的因素.
主要方法:
- 在乔治亚州亚特兰大诊断出mopox的PWH队列研究 (2022年6月至10月).
- 患者被分为早期的特科维瑞马 (发病7天内) 或晚期/没有特科维瑞马的队列.
- 倾向性得分匹配被用来比较不同组之间的mopox疾病进展.
主要成果:
- 在匹配后,56名PWH接受了早期tecovirimat,56人接受了晚期/没有tecovirimat.
- 马波克斯病的进展发生在早期tecovirimat组的5.4%,而晚期/没有tecovirimat组的26.8%.
- 早期的特科维里马治疗与明显降低疾病进展的可能性有关 (配对OR,13.00;P=.002).
结论:
- 早期的特科维里马治疗与PWH中mopox疾病进展的减少有关.
- 这些发现支持对所有怀疑有mopox.pwH的PWH启动tecovirimat.
- 需要进一步的研究来证实这些结果.
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